5-Amino-1MQ

5-Amino-1MQ (5-amino-1-methylquinolinium) is a non-peptide small molecule investigated as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). Current interest centers on metabolic signaling, NAD+ availability, mitochondrial function, and adipocyte biology; human evidence remains limited.

Mechanism — By inhibiting NNMT, 5-Amino-1MQ is studied for reducing nicotinamide methylation and preserving metabolites involved in cellular NAD+ and methyl-donor pathways. Preclinical work examines downstream effects on mitochondrial energetics, fat oxidation, and adipocyte metabolism.