Dihexa
DIHXAngiotensin-derived nootropic peptide.
Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNB-0408
Overview
Dihexa is an angiotensin IV-derived peptide studied in synaptogenesis and cognition research, noted in literature for potent neurotrophic activity.
An angiotensin IV-derived compound reported in preclinical work to be orders of magnitude more potent than BDNF at promoting synaptogenesis — the formation of new neural connections. It acts via the hepatocyte growth factor (HGF)/c-Met system and is studied for memory and neurodegeneration.
Studied for augmenting hepatocyte growth factor (HGF)/c-Met signaling, promoting synapse formation.
Molecular information
N-hexanoic-Tyr-Ile-(6) aminohexanoic amide; lipophilic enough to cross the blood-brain barrier.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- Synaptogenesis research
- Cognitive-enhancement studies
- Neurotrophic-signaling investigations
Research protocols
Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
Week 1–2
Synaptogenic/HGF signaling reported in cognition research models.
Week 3–4
Memory and learning changes reported; cycles are typically kept short.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
Cyclic Glycine-Proline
Complementary IGF/HGF neurotrophic pathways.
Cerebrolysin
Complementary neurotrophic mechanisms.
P21
Complementary neurogenic pathways.
Quality indicators
Consistent form
Research material is typically a capsule or solution; verify labeled concentration.
Handle as potent
Reported to be extremely potent at low amounts — accurate measurement matters.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Because it strongly promotes growth-factor signaling, theoretical proliferation considerations are noted in the literature.
- Human data are essentially absent; evidence is preclinical and the compound is highly experimental.
References & further reading
Dihexa: angiotensin IV analog and synaptogenesis (preclinical)
Research reporting potent procognitive and synaptogenic effects via the HGF/c-Met system.
View studyTopics
This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Active but early-stage research; evidence still developing.
This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.
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