Semax
SMXNootropic and neuroprotective heptapeptide.
Also known as: ACTH(4-10) analog
Overview
Semax is a synthetic peptide derived from a fragment of ACTH studied in cognition, neuroprotection, and BDNF-related research.
A synthetic analog of an ACTH(4-10) fragment, widely used in Russia as a nootropic and neuroprotective agent. Research highlights increased BDNF expression, improved focus and memory, and neuroprotection in stroke and cognitive-stress models — without the hormonal effects of full ACTH.
Studied for increasing BDNF and NGF expression and modulating the dopaminergic and serotonergic systems.
Molecular information
Met-Glu-His-Phe-Pro-Gly-ProA Pro-Gly-Pro extension stabilizes the ACTH fragment against rapid breakdown.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- Cognitive-enhancement research
- Neuroprotection studies
- BDNF/NGF-pathway investigations
Research protocols
Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
Acute
Focus and alertness changes reported within ~30 minutes of intranasal dosing.
Week 1–4
BDNF-mediated cognitive and neuroprotective effects reported with continued use.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
NA-Semax Amidate
Stabilized variant of the same peptide — redundant.
Selank
Frequently paired (focus + anxiolytic) in nootropic research.
P21
Complementary neurogenic/BDNF pathways.
BPC-157
No known interactions, complementary mechanisms for stress response and neural protection
TB-500
Both support brain health and recovery, can be used together for comprehensive neuroprotection
How to reconstitute
Reconstitute with bacteriostatic water, swirl gently, and refrigerate. For intranasal use, many protocols prepare a metered spray.
- 1Allow the vial to reach room temperature (15–20 minutes).
- 2Swab the stopper with alcohol and let it air dry.
- 3Add bacteriostatic water slowly down the vial wall.
- 4Swirl gently until dissolved into a clear solution.
- 5Refrigerate at 2–8 °C and protect from light.
Quality indicators
Uniform white powder
Lyophilized cake should be white to off-white without discoloration.
Clear solution
Reconstitutes to a clear, colorless, particle-free solution.
Cold-chain integrity
Reconstituted solution requires 2–8 °C storage.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Generally reported as well tolerated; nasal irritation is the most common intranasal signal.
- Most clinical evidence originates from Russian research and is less replicated elsewhere.
References & further reading
Semax: ACTH(4-10) analog neuroprotection and cognition (review)
Review of Semax's BDNF-related cognitive and neuroprotective effects across stroke and cognitive models.
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This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Substantial peer-reviewed research across multiple models.
Semax is stocked as a research-grade compound, ≥99% by HPLC, third-party verified.
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