Sexual & Reproductive

Emerging Research

Kisspeptin

KISS

Upstream regulator of reproductive hormones.

Also known as: Kisspeptin-10, Metastin

Research dose rangeMicrogram-to-nanomole range (research models)

Route studiedSubcutaneous / intravenous

Study durationPer protocol (often pulsatile)

Storage2–8 °C reconstituted

Overview

Kisspeptin is a neuropeptide studied in reproductive-axis and fertility research as a key upstream regulator of GnRH signaling.

Key research findings

A neuropeptide that sits at the top of the reproductive hormonal axis, triggering GnRH release and thereby driving the entire downstream LH/FSH/sex-hormone cascade. Research explores it for fertility, hypothalamic amenorrhea, and as a more physiologic way to stimulate reproductive function.

Mechanism of action

Activates the KISS1 receptor on GnRH neurons, stimulating downstream release of LH and FSH in the reproductive axis.

Molecular information

Weight~1,300–2,400 Da (varies by fragment)

LengthActive fragments (e.g., kisspeptin-10/-54)

TypeGnRH-stimulating neuropeptide (KISS1)

Encoded by KISS1; signals via the KISS1R/GPR54 receptor to drive GnRH neurons.

Pharmacokinetics

Peak: ~0.5 hoursHalf-life: ~Minutes (kisspeptin-10 short; -54 longer)Cleared: ~12 hours

Peak · 1hHalf-life · 2h

Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.

Research applications

Reproductive-axis research
Fertility studies
Neuroendocrine investigations

Research protocols

Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.

Research goalReference amountFrequencyRoute

Reference (bolus)Amount: Per protocolFrequency: Single/intermittentRoute: Subcutaneous

Reference (pulsatile)Amount: Per protocolFrequency: Pulsatile infusionRoute: Intravenous

Observed effects timeline

Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.

Acute
GnRH-driven LH/FSH release reported within ~30 minutes in study models.
Ongoing
Reproductive-axis activation and fertility-marker changes reported in research.

Research compatibility

Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.

HCG

Acts further downstream on the gonads; different axis point.

Compatible

TRT

Exogenous androgens suppress the axis kisspeptin stimulates.

Use caution

Oxytocin

Distinct reproductive/behavioral pathways.

Compatible

How to reconstitute

Important

Reconstitute with bacteriostatic water, swirl gently, and refrigerate. Avoid shaking to preserve the peptide.

1Allow the vial to reach room temperature (15–20 minutes).
2Swab the stopper with alcohol and let it air dry.
3Add bacteriostatic water slowly down the vial wall.
4Swirl gently until dissolved into a clear solution.
5Refrigerate at 2–8 °C and protect from light.

Open reconstitution calculator

Quality indicators

Uniform white powder

Lyophilized cake should be white to off-white without discoloration.

Clear solution

Reconstitutes to a clear, colorless, particle-free solution.

Cold-chain integrity

Reconstituted solution requires 2–8 °C storage.

Slight clumping

Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.

Collapsed or melted appearance

Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.

Cloudy after reconstitution

Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.

Reported observations & safety

Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.

Generally reported as well tolerated in clinical research; it acts physiologically on the reproductive axis.
An active area of human reproductive-endocrinology research with multiple clinical studies.

References & further reading

Kisspeptin in reproductive physiology (review)

HumanKISS1RGnRH axis

Review of kisspeptin's role as the master regulator triggering GnRH release and reproductive function.

View study

Topics

reproductivegnrhneuropeptide

This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.

Research level

Emerging Research

Active but early-stage research; evidence still developing.

Quick reference

Dose rangeMicrogram-to-nanomole range (research models)

RouteSubcutaneous / intravenous

DurationPer protocol (often pulsatile)

Storage2–8 °C reconstituted

Half-life~Minutes (kisspeptin-10 short; -54 longer)

Catalogue status

This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.

Browse catalogue