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Sexual & Reproductive
FDA Approved

Oxytocin

OXT

Nonapeptide hormone studied in social and reproductive behavior.

Also known as: Pitocin

Research dose range10–40 IU intranasal (research models)
Route studiedIntranasal / subcutaneous
Study durationPer protocol
Storage2–8 °C reconstituted

Overview

Oxytocin is a nine-amino-acid neuropeptide hormone studied extensively in social bonding, reproductive physiology, and neuroendocrine research.

Key research findings

A nine-amino-acid neuropeptide hormone central to social bonding, trust, and reproductive physiology. Beyond its approved obstetric use, research explores intranasal oxytocin for social cognition, anxiety, and relationship-related behaviors.

Mechanism of action

Binds oxytocin receptors in the central nervous system and peripheral tissues, influencing smooth-muscle contraction and social-behavior circuits.

Molecular information

Weight1,007 Da
Length9 amino acids
TypeNonapeptide neurohypophyseal hormone
Amino-acid sequenceCys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (disulfide bridge)

Differs from vasopressin by only two residues; features an internal disulfide bond.

Pharmacokinetics

Peak: ~0.25 hours (intranasal)Half-life: ~Minutes (very short)Cleared: ~12 hours
Peak · 0hHalf-life · 2h

Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.

Research applications

  • Social-behavior and bonding research
  • Reproductive physiology studies
  • Neuroendocrine signaling investigations

Research protocols

Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.

Social-cognition referenceAmount: 20–24 IUFrequency: Per sessionRoute: Intranasal
Conservative referenceAmount: 10 IUFrequency: Per sessionRoute: Intranasal

Observed effects timeline

Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.

  1. Acute

    Social-bonding and anxiolytic effects reported within ~30 minutes of intranasal dosing.

  2. Ongoing

    Behavioral and mood-related effects reported with repeated research use.

Research compatibility

Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.

Kisspeptin

Distinct reproductive/behavioral pathways.

Compatible

PT-141

Complementary in sexual-behavior research contexts.

Compatible

How to reconstitute

Important

Reconstitute with bacteriostatic water, swirl gently, and refrigerate. Oxytocin is fragile — avoid heat and agitation.

  1. 1Allow the vial to reach room temperature (15–20 minutes).
  2. 2Swab the stopper with alcohol and let it air dry.
  3. 3Add bacteriostatic water slowly down the vial wall.
  4. 4Swirl gently until dissolved — do not shake.
  5. 5Refrigerate at 2–8 °C and protect from light.
Open reconstitution calculator

Quality indicators

Uniform white powder

Lyophilized cake should be white to off-white without discoloration.

Clear solution

Reconstitutes to a clear, colorless, particle-free solution.

Cold-chain integrity

Reconstituted solution requires 2–8 °C storage.

Slight clumping

Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.

Collapsed or melted appearance

Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.

Cloudy after reconstitution

Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.

Reported observations & safety

Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.

  • An FDA-approved hormone (obstetric use); intranasal research use is generally reported as well tolerated.
  • High or frequent dosing can have paradoxical or context-dependent behavioral effects in research.

References & further reading

Intranasal oxytocin and social cognition (review)

Humanneuropeptidesocial behavior

Review of oxytocin's effects on social bonding, trust, and anxiety in behavioral research.

View study

Topics

neuropeptidebehaviorhormone

This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.

Research level
FDA Approved

Approved for one or more clinical indications by a major regulator.

Quick reference
Dose range10–40 IU intranasal (research models)
RouteIntranasal / subcutaneous
DurationPer protocol
Storage2–8 °C reconstituted
Half-life~Minutes (very short)
Catalogue status

This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.

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