KPV
KPVAnti-inflammatory tripeptide.
Also known as: Lysine-Proline-Valine, α-MSH(11-13)
Overview
KPV is a tripeptide fragment of alpha-MSH studied in anti-inflammatory and gut-health research models.
The C-terminal tripeptide of alpha-MSH (Lys-Pro-Val), studied for potent anti-inflammatory activity without the pigmentation effects of full alpha-MSH. Research focuses on gut inflammation (IBD models) and skin, where it can act both systemically and topically.
Studied for entering cells and modulating inflammatory signaling (NF-kB pathway) without the pigmentary effects of full alpha-MSH.
Molecular information
Lys-Pro-ValThe minimal anti-inflammatory fragment of alpha-MSH, lacking melanocortin pigment activity.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- Anti-inflammatory research
- Gut-health studies
- Immune-modulation investigations
Research protocols
Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
Week 1–2
Onset of anti-inflammatory signaling reported in gut/skin research models.
Week 4+
Sustained inflammation-modulating effects reported with continued use.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
BPC-157
Frequently co-studied for gut-healing and anti-inflammatory pathways.
LL-37
Complementary host-defense/anti-inflammatory signaling.
Thymosin Alpha-1
Distinct immune-modulating mechanism.
TB-500
Both have anti-inflammatory properties through different pathways - may work well together
Melanotan II
KPV is derived from a-MSH like MT-II but without tanning effects - using both is unnecessary
GHK-Cu
Excellent combination for skin health - GHK-Cu promotes collagen while KPV reduces inflammation
How to reconstitute
Reconstitute with bacteriostatic water, swirl gently, and refrigerate. Avoid shaking to preserve the peptide.
- 1Allow the vial to reach room temperature (15–20 minutes).
- 2Swab the stopper with alcohol and let it air dry.
- 3Add bacteriostatic water slowly down the vial wall.
- 4Swirl gently until dissolved into a clear solution.
- 5Refrigerate at 2–8 °C and protect from light.
Quality indicators
Uniform white powder
Lyophilized cake should be white to off-white without discoloration.
Clear solution
Reconstitutes to a clear, colorless, particle-free solution.
Cold-chain integrity
Reconstituted solution requires 2–8 °C storage.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Generally reported as well tolerated; mild injection-site reactions are the most common signal.
- Unlike full alpha-MSH, it does not stimulate pigmentation.
References & further reading
KPV tripeptide anti-inflammatory activity (review)
Review of the KPV tripeptide's anti-inflammatory actions in intestinal and dermal research models.
View studyTopics
This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Active but early-stage research; evidence still developing.
This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.
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