VIP
VIPNeuropeptide studied in immune and vascular research.
Also known as: Vasoactive Intestinal Peptide
Overview
VIP (Vasoactive Intestinal Peptide) is a neuropeptide studied in immune-modulation, vascular, and inflammatory research.
Vasoactive Intestinal Peptide is a 28-amino-acid neuropeptide with broad anti-inflammatory, immune-modulating, and vasodilatory roles. It is studied notably as an intranasal protocol in chronic inflammatory response syndrome (CIRS) research and for pulmonary and gut applications.
Binds VPAC receptors to influence vasodilation, anti-inflammatory signaling, and circadian regulation.
Molecular information
A member of the secretin/glucagon peptide superfamily; signals via VPAC receptors.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- Immune-modulation research
- Vascular studies
- Inflammation and circadian investigations
Research protocols
Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
Acute
Vasodilatory and anti-inflammatory signaling reported shortly after dosing.
Week 4+
Changes in inflammatory and pulmonary markers reported in CIRS research protocols.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
KPV
Complementary anti-inflammatory pathways.
Thymosin Alpha-1
Distinct immune-modulating mechanism.
DSIP
Distinct neuropeptide pathways.
How to reconstitute
Reconstitute with bacteriostatic water, swirl gently, and refrigerate. VIP is very fragile — handle gently and keep cold.
- 1Allow the vial to reach room temperature (15–20 minutes).
- 2Swab the stopper with alcohol and let it air dry.
- 3Add bacteriostatic water slowly down the vial wall.
- 4Swirl gently until dissolved — do not shake.
- 5Refrigerate at 2–8 °C and protect from light.
Quality indicators
Uniform white powder
Lyophilized cake should be white to off-white without discoloration.
Clear solution
Reconstitutes to a clear, colorless, particle-free solution.
Cold-chain integrity
Reconstituted solution requires 2–8 °C storage.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Flushing, lowered blood pressure, and lightheadedness are reported due to vasodilatory activity.
- CIRS research protocols emphasize addressing underlying exposures before VIP use.
References & further reading
Vasoactive intestinal peptide: immune and vascular roles (review)
Review of VIP's broad anti-inflammatory, immune-modulating, and vasodilatory actions.
View studyTopics
This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Sparse published data; largely preliminary or anecdotal.
This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.
Browse catalogue