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Cognitive & Nootropic
Well Researched

Bromantane

BROM

Actoprotector studied in fatigue and cognition.

Also known as: Ladasten, ADK-709

Research dose range50–100 mg daily (research models)
Route studiedOral
Study durationDaily, short-to-medium courses
StorageRoom temperature (dry)

Overview

Bromantane is an actoprotector studied in fatigue-resistance, cognition, and physical-performance research, noted for combining stimulant and anxiolytic-like profiles.

Key research findings

An 'actoprotector' (anti-fatigue) compound developed in Russia, unusual for combining mild stimulant and anxiolytic effects. Research suggests it enhances dopamine synthesis by upregulating tyrosine hydroxylase, improving endurance and mental performance under stress without typical stimulant crash.

Mechanism of action

Studied for upregulating dopamine biosynthesis enzymes (tyrosine hydroxylase), supporting sustained dopaminergic signaling.

Molecular information

Weight~310 Da
LengthNon-peptide small molecule
TypeAdamantane-derivative actoprotector

An adamantane compound; not a peptide. Acts partly via dopamine-synthesis gene regulation.

Pharmacokinetics

Peak: ~2–3 hoursHalf-life: ~11 hoursCleared: ~3 days
Peak · 0.1dHalf-life · 0.5d

Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.

Research applications

  • Fatigue-resistance research
  • Cognitive-performance studies
  • Dopaminergic-signaling investigations

Research protocols

Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.

Conservative referenceAmount: 50 mgFrequency: Once daily (AM)Route: Oral
Standard referenceAmount: 100 mgFrequency: Once daily (AM)Route: Oral

Observed effects timeline

Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.

  1. Acute

    Anti-fatigue and mild stimulant effects reported within a few hours.

  2. Week 1–3

    Endurance and stress-resilience changes reported; tolerance is low in research.

Research compatibility

Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.

Semax

Complementary focus/energy nootropic pathways.

Compatible

Selank

Energy plus anxiolytic balance studied together.

Compatible

Stimulants

Additive dopaminergic/stimulant effects — monitor.

Use caution

Quality indicators

Consistent oral form

Research material is typically a capsule or tablet; verify labeled concentration.

Dry storage

As a stable small molecule, it does not require cold-chain handling.

Slight clumping

Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.

Collapsed or melted appearance

Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.

Cloudy after reconstitution

Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.

Reported observations & safety

Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.

  • Generally reported as well tolerated with low dependence potential in the research literature.
  • Most evidence originates from Russian research and is less replicated elsewhere; it is a doping-banned substance in sport.

References & further reading

Bromantane: actoprotector and dopaminergic effects (review)

Human/preclinicaldopamineanti-fatigue

Review of bromantane's combined stimulant/anxiolytic profile and dopamine-synthesis upregulation.

View study

Topics

nootropicdopaminefatigue

This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.

Research level
Well Researched

Substantial peer-reviewed research across multiple models.

Quick reference
Dose range50–100 mg daily (research models)
RouteOral
DurationDaily, short-to-medium courses
StorageRoom temperature (dry)
Half-life~11 hours
Catalogue status

This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.

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