Epitalon
EPITetrapeptide studied in telomere and pineal research.
Also known as: Epithalon, Epithalamin
Overview
Epitalon is a synthetic tetrapeptide studied in telomere, circadian, and pineal-gland research, derived from the natural peptide epithalamin.
A short tetrapeptide derived from the pineal peptide epithalamin, studied in Russian research for telomerase activation, circadian/melatonin regulation, and lifespan extension in animal models. Human data remain limited and largely originate from a small number of study groups.
Studied for stimulating telomerase activity and modulating melatonin/pineal signaling in aging models.
Molecular information
Ala-Glu-Asp-GlyA synthetic, sequence-defined analog of the natural pineal extract epithalamin.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- Telomere and cellular-aging research
- Circadian-rhythm studies
- Pineal-function investigations
Research protocols
Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
Cycle (10–20 days)
Administration concentrated into short cycles rather than continuous use in study designs.
Between cycles
Effects on circadian and antioxidant markers reported to persist beyond the dosing window in models.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
Pinealon
Related pineal/peptide-bioregulator research.
NAD+
Co-studied in longevity contexts.
SS-31
Complementary cellular-aging pathways.
Semax
No direct interactions - Epitalon focuses on cellular aging while these target neurocognitive function
Selank
No direct interactions - Epitalon focuses on cellular aging while these target neurocognitive function
BPC-157
Different mechanisms - can be used together safely for comprehensive regenerative support
How to reconstitute
Reconstitute with bacteriostatic water, swirl gently, and refrigerate. Use within the typical ~28-day window — often 1–3 months if it stays clear.
- 1Allow the vial to reach room temperature.
- 2Swab the stopper with alcohol and let it air dry.
- 3Add bacteriostatic water slowly down the vial wall.
- 4Swirl gently until dissolved — do not shake.
- 5Refrigerate at 2–8 °C and protect from light.
Quality indicators
Uniform white powder
Lyophilized material should be white to off-white without discoloration.
Clear solution
Reconstitutes to a clear, colorless solution.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Generally reported as well tolerated in the available (limited) studies.
- Human evidence is sparse and largely from a small number of research groups.
References & further reading
Epithalon peptide and telomerase activity (preclinical)
Research reporting induction of telomerase activity and effects on cellular senescence markers in model systems.
View studyTopics
This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Substantial peer-reviewed research across multiple models.
This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.
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