FOXO4-DRI
FOXO4Senolytic research peptide.
Also known as: FOXO4-D-Retro-Inverso
Overview
FOXO4-DRI is a D-retro-inverso peptide studied in senolytic research for its targeting of senescent cells in aging models.
A designed 'senolytic' peptide that disrupts the FOXO4-p53 interaction in senescent ('zombie') cells, selectively triggering their apoptosis. In landmark mouse research it reduced markers of aging and restored fitness — making it one of the most discussed longevity research peptides.
Disrupts the FOXO4-p53 interaction in senescent cells, studied for selectively triggering their apoptosis (senolysis).
Molecular information
A D-retro-inverso (DRI) peptide engineered for protease resistance and cellular uptake.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- Senolytic research
- Cellular-senescence studies
- Longevity investigations
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
Pulse (research)
Selective clearance of senescent cells reported in animal models after intermittent dosing.
Post-pulse
Improvements in aging markers and tissue function reported in preclinical studies.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
Epitalon
Complementary longevity pathways in research.
NAD+
Complementary cellular-health support.
SS-31
Complementary mitochondrial-protection pathway.
How to reconstitute
Reconstitute with bacteriostatic water, swirl gently, and refrigerate. Avoid shaking to preserve the peptide.
- 1Allow the vial to reach room temperature (15–20 minutes).
- 2Swab the stopper with alcohol and let it air dry.
- 3Add bacteriostatic water slowly down the vial wall.
- 4Swirl gently until dissolved into a clear solution.
- 5Refrigerate at 2–8 °C and protect from light.
Quality indicators
Uniform white powder
Lyophilized cake should be white to off-white without discoloration.
Clear solution
Reconstitutes to a clear, colorless, particle-free solution.
Cold-chain integrity
Reconstituted solution requires 2–8 °C storage.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Highly experimental — because it triggers targeted cell death, off-target and dosing risks are emphasized in the literature.
- No established human safety profile; all current evidence is preclinical.
References & further reading
Targeted apoptosis of senescent cells via FOXO4-DRI (Cell, 2017)
Landmark research reporting selective clearance of senescent cells and restored fitness in aged mice.
View studyTopics
This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Active but early-stage research; evidence still developing.
This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.
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