Hexarelin
HEXAPotent growth-hormone secretagogue.
Also known as: Examorelin
Overview
Hexarelin is a synthetic hexapeptide growth-hormone secretagogue studied for potent GH-release and cardiovascular-research applications.
One of the most potent GHRPs by weight, studied for strong GH release and for direct cardiovascular effects via CD36 receptors that are independent of GH. Unlike GHRP-6, it does not strongly stimulate appetite, but it can raise cortisol/prolactin at higher amounts.
Activates the ghrelin/GH-secretagogue receptor and is studied for additional cardiac CD36-receptor interactions.
Molecular information
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2A potent synthetic hexapeptide acting at the ghrelin/GH-secretagogue and CD36 receptors.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- GH-release research
- Cardiovascular-signaling studies
- Secretagogue-pathway investigations
Research protocols
Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
Acute (per dose)
Strong GH pulse reported within ~30 minutes of administration.
Week 2–4
IGF-1 elevation reported; desensitization can occur with prolonged high use.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
GHRP-6
Redundant GHRP activity.
Ipamorelin
Overlapping secretagogue mechanism.
CJC-1295 (no DAC)
GHRH + GHRP synergy in research.
How to reconstitute
Reconstitute with bacteriostatic water, swirl gently, and refrigerate. Avoid shaking to preserve the peptide.
- 1Allow the vial to reach room temperature (15–20 minutes).
- 2Swab the stopper with alcohol and let it air dry.
- 3Add bacteriostatic water slowly down the vial wall.
- 4Swirl gently until dissolved into a clear solution.
- 5Refrigerate at 2–8 °C and protect from light.
Quality indicators
Uniform white powder
Lyophilized cake should be white to off-white without discoloration.
Clear solution
Reconstitutes to a clear, colorless, particle-free solution.
Cold-chain integrity
Reconstituted solution requires 2–8 °C storage.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Cortisol and prolactin elevation are reported, more so than with ipamorelin.
- Desensitization with prolonged high use is noted; shorter cycles are common in research designs.
References & further reading
Hexarelin: GH secretagogue and cardiovascular effects (review)
Review of hexarelin's potent GH-releasing action and GH-independent cardiovascular effects via CD36.
View studyTopics
This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Substantial peer-reviewed research across multiple models.
This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.
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