CJC-1295 (No DAC)
CJCShort-acting GHRH analog.
Also known as: Mod GRF 1-29, CJC-1295 without DAC
Overview
CJC-1295 without DAC (Mod GRF 1-29) is a growth-hormone-releasing hormone analog studied for its short half-life and pulsatile GH-release profile.
The short-acting GHRH analog (often called Mod-GRF 1-29 or CJC-1295 without DAC), studied for producing clean, pulsatile GH release that more closely mimics natural rhythms than the long-acting DAC version. Commonly paired with a GHRP such as ipamorelin.
Binds GHRH receptors on the pituitary to trigger a sharp, short-lived pulse of growth-hormone release.
Molecular information
GHRH(1-29) with four stabilizing substitutions but no albumin-binding DAC linker.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- Pulsatile GH-release research
- GH-axis studies
- Secretagogue-combination investigations
Research protocols
Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
Acute (per dose)
Clean GH pulse reported within ~30 minutes; short duration preserves natural rhythm.
Week 2–4
Cumulative IGF-1 elevation reported with consistent dosing.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
Ipamorelin
Classic GHRH + GHRP pulsatile-release pairing.
CJC-1295 (with DAC)
Redundant GHRH-receptor activation.
GHRP-6
Synergistic GH pulses when co-administered.
Tesamorelin
Both bind to pituitary GHRH receptors. Combining saturates receptors without amplifying GH release, risking receptor desensitization and blunted pulsatility. Choose one based on your protocol goals.
MK-677
Different mechanisms - MK-677 provides continuous ghrelin stimulation while CJC-1295 offers pulsatile GHRH
Hexarelin
Can be combined but monitor for excessive GH elevation due to Hexarelin's potency
How to reconstitute
Reconstitute with bacteriostatic water, swirl gently, and refrigerate. Avoid shaking to preserve the peptide.
- 1Allow the vial to reach room temperature (15–20 minutes).
- 2Swab the stopper with alcohol and let it air dry.
- 3Add bacteriostatic water slowly down the vial wall.
- 4Swirl gently until dissolved into a clear solution.
- 5Refrigerate at 2–8 °C and protect from light.
Quality indicators
Uniform white powder
Lyophilized cake should be white to off-white without discoloration.
Clear solution
Reconstitutes to a clear, colorless, particle-free solution.
Cold-chain integrity
Reconstituted solution requires 2–8 °C storage.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Generally well tolerated; transient flushing/head-rush and injection-site reactions reported.
- Shorter action than the DAC version means more frequent dosing in study designs.
References & further reading
Modified GRF(1-29) GHRH analog pharmacology (review)
Review of the short-acting modified GHRH analog and its pulsatile GH-releasing profile.
View studyTopics
This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Substantial peer-reviewed research across multiple models.
CJC-1295 (No DAC) is stocked as a research-grade compound, ≥99% by HPLC, third-party verified.
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