CJC-1295 with DAC
CJC-DACLong-acting GHRH analog with extended half-life.
Also known as: Drug Affinity Complex CJC-1295
Overview
CJC-1295 with DAC is a GHRH analog bound to a drug-affinity complex that extends its half-life, studied for sustained elevation of GH and IGF-1 in research models.
The drug-affinity-complex (DAC) version binds serum albumin to extend half-life to roughly a week, producing a sustained 'GH bleed' rather than sharp pulses in research models. Frequently studied alongside a GHRP (e.g. ipamorelin) for combined GH-release effects.
The DAC moiety binds serum albumin, prolonging circulation and producing a sustained increase in GH-releasing activity.
Molecular information
Modified GHRH(1-29) with four stabilizing substitutions plus a maleimidopropionic-acid (DAC) linker for albumin binding.DAC conjugation forms a covalent albumin bond, extending circulation dramatically.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- Sustained GH-release research
- IGF-1 elevation studies
- Long-acting analog investigations
Research protocols
Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
Week 1–2
Sustained elevation of GH and IGF-1 reported as albumin-bound depot accumulates.
Week 4–8
Stable IGF-1 elevation reported across study cohorts.
Ongoing
Steady-state GH-axis stimulation maintained with weekly administration.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
Ipamorelin
GHRH + GHRP combinations studied for synergistic GH release.
Tesamorelin
Redundant GHRH-receptor activation.
Sermorelin
Overlapping GHRH activity.
MK-677
Both elevate GH/IGF-1 via different routes; monitor in research.
GHRP-6
GHRP pulse effects are diminished when combined with continuous GH elevation from CJC-1295 DAC
CJC-1295 (No DAC)
Never combine different CJC-1295 variants - choose based on desired release pattern
HGH
Combining with exogenous HGH defeats the purpose and may suppress natural production
How to reconstitute
Reconstitute with bacteriostatic water, swirl gently, and refrigerate. Avoid shaking to preserve peptide integrity.
- 1Allow the vial to reach room temperature (15–20 minutes).
- 2Swab the stopper with alcohol and let it air dry.
- 3Add bacteriostatic water slowly down the vial wall.
- 4Swirl gently until dissolved — do not shake.
- 5Refrigerate at 2–8 °C and protect from light.
Quality indicators
Uniform white powder
Lyophilized cake should be white to off-white without discoloration.
Clear solution
Reconstitutes to a clear, colorless, particle-free solution.
Cold-chain integrity
Reconstituted solution requires 2–8 °C storage.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Injection-site reactions and transient water retention are commonly reported.
- Sustained GH elevation differs from pulsatile analogs; IGF-1 monitoring is standard in research.
References & further reading
Long-acting GHRH analog (CJC-1295) pharmacodynamics (JCEM, 2006)
Study reporting prolonged elevation of GH and IGF-1 following single doses of the DAC-modified GHRH analog.
View studyTopics
This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Substantial peer-reviewed research across multiple models.
This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.
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