Sermorelin
SERMFoundational GHRH analog.
Also known as: GRF 1-29, GHRH(1-29)
Overview
Sermorelin is a synthetic analog of the first 29 amino acids of GHRH, one of the foundational secretagogue research compounds for studying endogenous GH release.
The original GHRH analog (the active 1-29 fragment of human GHRH), with the longest clinical history in this class — it was once an approved diagnostic and pediatric GH agent. It stimulates the pituitary to release GH in a physiologic, pulsatile manner.
Binds GHRH receptors on the pituitary to stimulate natural, pulsatile growth-hormone production.
Molecular information
The shortest fully active fragment of the 44-residue human GHRH molecule.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- Endogenous GH-release research
- GH-axis studies
- Aging and body-composition investigations
Research protocols
Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
Acute (per dose)
Physiologic GH pulse reported shortly after administration.
Week 4–12
Gradual IGF-1 elevation and recovery/sleep changes reported in cohorts.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
CJC-1295 (with DAC)
Redundant GHRH-receptor activation.
Tesamorelin
Overlapping GHRH activity.
Ipamorelin
GHRH + GHRP synergy studied for amplified pulses.
How to reconstitute
Reconstitute with bacteriostatic water, swirl gently, and refrigerate. Sermorelin is fragile and degrades with heat or agitation.
- 1Allow the vial to reach room temperature (15��20 minutes).
- 2Swab the stopper with alcohol and let it air dry.
- 3Add bacteriostatic water slowly down the vial wall.
- 4Swirl gently until dissolved — do not shake.
- 5Refrigerate at 2–8 °C and protect from light.
Quality indicators
Uniform white powder
Lyophilized cake should be white to off-white without discoloration.
Clear solution
Reconstitutes to a clear, colorless, particle-free solution.
Cold-chain integrity
Reconstituted solution requires 2–8 °C storage.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Among the best-tolerated GH-axis agents, with a long clinical-safety history.
- Injection-site reactions and occasional flushing are the most commonly reported signals.
References & further reading
Sermorelin (GHRH 1-29) in GH evaluation and therapy (review)
Review of the GHRH(1-29) analog's history in growth-hormone diagnostics and stimulation.
Topics
This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Substantial peer-reviewed research across multiple models.
This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.
Browse catalogue