PE-22-28
PE-22TREK-1 channel blocker studied in mood research.
Also known as: Mini-Spadin, Spadin analog
Overview
PE-22-28 is a synthetic peptide analog of spadin studied in mood-regulation and neuroplasticity research.
A 7-amino-acid fragment of the neuroprotective protein spadin, studied as a TREK-1 potassium-channel blocker. Because TREK-1 inhibition is a proposed fast-acting antidepressant mechanism, research interest centers on rapid mood effects and neuroplasticity.
Studied for blocking the TREK-1 potassium channel, a target investigated in fast-acting mood-modulation research.
Molecular information
Derived from the propeptide of sortilin (spadin); targets the TREK-1 background K+ channel.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- Mood-regulation research
- Neuroplasticity studies
- Ion-channel investigations
Research protocols
Protocols summarized from published research models. Provided for scientific reference only — not dosing guidance for human use.
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
Acute–Week 1
Mood and neuroplasticity signaling reported relatively rapidly in study models (TREK-1 mechanism).
Week 2–4
Antidepressant-like and neuroplastic changes reported with continued use.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
Semax
Complementary BDNF/neuroplasticity pathways.
Selank
Complementary mood/anxiolytic mechanisms.
DSIP
Distinct neuropeptide pathways.
How to reconstitute
Reconstitute with bacteriostatic water, swirl gently, and refrigerate. Avoid shaking to preserve the peptide.
- 1Allow the vial to reach room temperature (15–20 minutes).
- 2Swab the stopper with alcohol and let it air dry.
- 3Add bacteriostatic water slowly down the vial wall.
- 4Swirl gently until dissolved into a clear solution.
- 5Refrigerate at 2–8 °C and protect from light.
Quality indicators
Uniform white powder
Lyophilized cake should be white to off-white without discoloration.
Clear solution
Reconstitutes to a clear, colorless, particle-free solution.
Cold-chain integrity
Reconstituted solution requires 2–8 °C storage.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Human data are essentially absent; evidence is preclinical and the peptide is experimental.
- The TREK-1 mechanism is of high research interest for fast-acting antidepressant pathways.
References & further reading
Spadin and PE 22-28: TREK-1 inhibition and antidepressant effects (preclinical)
Research on spadin-derived peptides blocking TREK-1 channels and producing antidepressant-like effects.
View studyTopics
This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Active but early-stage research; evidence still developing.
This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.
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