PNC-27
PNC-27Membrane-targeting research peptide.
Also known as: p53-derived anticancer peptide
Overview
PNC-27 is a p53-derived peptide studied in cell-membrane and cancer-research models for its selective interaction with certain cell membranes.
A highly experimental designed peptide combining a p53-derived domain with a membrane-penetrating (HDM-2-binding) region, studied in cancer-cell research for selectively disrupting the membranes of cancer cells while reportedly sparing normal cells. Strictly a preclinical research compound.
Studied for binding HDM-2 in cell membranes and forming pores that selectively affect targeted cells in research models.
Molecular information
Fuses a p53 residues 12-26 domain with the penetratin membrane-resident peptide.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- Cell-membrane research
- Targeted-cell studies
- p53-pathway investigations
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
In vitro
Selective cancer-cell membrane disruption reported in cell-culture research.
Research status
No human data; mechanism and safety are still being characterized.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
FOXO4-DRI
Both are experimental p53-pathway research peptides.
Epitalon
Distinct longevity pathway.
How to reconstitute
Reconstitute with bacteriostatic water, swirl gently, and refrigerate. Handle as an experimental research compound.
- 1Allow the vial to reach room temperature (15–20 minutes).
- 2Swab the stopper with alcohol and let it air dry.
- 3Add bacteriostatic water slowly down the vial wall.
- 4Swirl gently until dissolved into a clear solution.
- 5Refrigerate at 2–8 °C and protect from light.
Quality indicators
Uniform white powder
Lyophilized cake should be white to off-white without discoloration.
Clear solution
Reconstitutes to a clear, colorless, particle-free solution.
Investigational
Limited characterization — handle as an experimental research chemical.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Among the most experimental entries here — strictly a preclinical cancer-research tool.
- No established human safety profile; all current evidence is in vitro or animal-based.
References & further reading
PNC-27 membrane disruption of cancer cells (preclinical)
Research reporting selective necrosis of cancer cells via membrane pore formation by the p53-derived peptide.
View studyTopics
This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Active but early-stage research; evidence still developing.
This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.
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