Adipotide
ADIPOPro-apoptotic peptide studied in adipose research.
Also known as: Prohibitin-TP01, FTPP
Overview
Adipotide is a peptidomimetic studied in adipose-tissue research for its targeting of the blood supply to fat tissue in preclinical models.
An experimental pro-apoptotic peptide that targets prohibitin on the vasculature feeding white adipose tissue, studied in animal models for rapid fat-mass reduction by cutting the blood supply to fat cells. A genuinely investigational compound — most data are preclinical (including primate studies).
Targets prohibitin on adipose-vasculature endothelium, studied for triggering apoptosis of fat-tissue blood supply.
Molecular information
CKGGRAKDC cyclic homing peptide fused to a D(KLAKLAK)₂ pro-apoptotic domain.Also called Prohibitin-TP01; the homing motif directs the apoptotic domain to adipose vasculature.
Pharmacokinetics
Illustrative relative-concentration model derived from published pharmacokinetic research. Curve is normalized and provided for educational comparison only — not a dosing schedule.
Research applications
- Adipose-vasculature research
- Body-composition studies
- Targeted-apoptosis investigations
Observed effects timeline
Aggregated observations reported across research literature. Timing and magnitude vary by model and are not a guarantee of outcome.
Preclinical courses
Animal studies report rapid fat-mass reduction over short experimental treatment windows.
Post-treatment
Weight regain reported after cessation in some models.
Research compatibility
Describes how compounds are studied alongside one another in the literature. Not a recommendation to co-administer.
AOD-9604
Both target adipose by different mechanisms; no human combination data.
Tesofensine
Distinct mechanisms; investigational status warrants caution.
How to reconstitute
Reconstitute with bacteriostatic water, swirl gently, and refrigerate. This is a highly investigational compound with very limited safety characterization.
- 1Allow the vial to reach room temperature.
- 2Swab the stopper with alcohol and let it air dry.
- 3Add bacteriostatic water slowly down the vial wall.
- 4Swirl gently until dissolved — do not shake.
- 5Refrigerate at 2–8 °C and protect from light.
Quality indicators
White, uniform cake
Lyophilized powder should be a white to off-white cake with no discoloration, filling the base of the vial.
Clear solution after reconstitution
With bacteriostatic water, the solution should turn crystal clear and colorless, with no visible particles.
Slight clumping
Small clumps that dissolve completely with gentle swirling are acceptable — shipping can cause minor compaction.
Collapsed or melted appearance
Powder that looks collapsed, melted, or stuck to the vial walls may have been exposed to heat in transit.
Cloudy after reconstitution
Persistent cloudiness, particles, or precipitate after gentle mixing can indicate a degraded or contaminated peptide.
Reported observations & safety
Safety signals reported in the research literature. Compiled for scientific awareness — not medical advice.
- Renal effects were observed in primate studies, a key safety signal in the preclinical literature.
- No established human safety profile — among the most experimental entries in this database.
References & further reading
Adipotide (prohibitin-targeting peptide) in primates (Science Translational Medicine, 2011)
Study reporting rapid weight reduction via targeted ablation of adipose blood supply, with observed renal effects.
View studyTopics
This entry is provided for educational and informational purposes only. It is not medical advice, a dosing protocol, or a claim of therapeutic benefit. Research compounds are supplied strictly for laboratory and research use — not for human or veterinary consumption.
Active but early-stage research; evidence still developing.
This compound is part of our educational reference and is not currently stocked. Browse the catalogue for available research-grade peptides.
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